Beneficial effect of microsurgical varicocelectomy on human sperm DNA integrity.

P-72: Effect of Subinguinal Varicocelectomy on Human Sperm DNA Integrity and Semen Parameters

Background: Varicocele occurs in approximately 15% to 20% of the male population and it is the most common cause of poor semen parameters. It has been demonstrated that patients with varicocele have poor chromatin packing, DNA damage and nuclear anomalies than the healthy men. Therefore, the aim of this study was to evaluate sperm chromatin integrity and semen parameters in these patients after...

Beneficial effects of microsurgical varicocoelectomy on sperm maturation, DNA fragmentation, and nuclear sulfhydryl groups: a prospective trial.

There is evidence to show that varicocele repair can improve conventional sperm parameters but the effects on sperm chromatin integrity have not been fully elucidated. We sought to examine the effects of varicocelectomy on sperm maturation, nuclear chromatin integrity and nuclear sulfhydryl groups. We conducted a prospective study of consecutive infertile men (n=29) that underwent a microsurgic...

Increased Sperm DNA Damage in Experimental Rat Varicocele Model and The Beneficial Effect of Varicocelectomy

P-59: Effect of Microsurgical Varicocelectomy on Sperm Chromatin Packaging,Miscarriage and Pregnancy Rate in Infertile Men with Varicocele

Background: Although the pathophysiology of the testicular damage associated with varicocele remains unclear, but varicocelectomy is considered a suitable technique for the treatment of individuals with clinical varicocele. The current study was designed to assessed semen parameters, chromatin packaging, and pregnancy outcome before and after varicocelectomy. Materials and Methods: Semen sample...

P-4: Zaditen (Ketotifen), as Mast Cell Blocker, Improves Sperm Quality, Chromatin Integrity and Pregnancy Rate after Varicocelectomy

Background: Surgery is considered the most common choice for the treatment of male infertility with clinical varicocele. Increased numbers of mast cells (MCs) have been associated with different types of infertility, including varicocele. Despite there being different reports on improved fertility following administration of MC blockers, there is no report on the effect of a MC blocker on varic...